Curr Biol：分散注意力可有效加剧疼痛感

昨日，登载在该协会著名周刊Cell的子刊Current Biology上的一篇研究成果报告宣称，透过无意识干扰（好在）的作法可以使得呼吸困难减低，然而这种呼吸困难加重减低的振荡非常表现在头部。这项研究成果发掘出是基于使用高分辨率的肝脏机能性磁共振成像新科技（fMRI新科技），对人们由于高热引起的呼吸困难素质进行研究成果，研究成果探究，无意识干扰确实可以在中枢呼吸困难处置早期减缓呼吸困难信号的传入。来自杜伊斯堡-埃庞多夫大学医学院的研究成果成果Christian Sprenger回应，这种现象非常仅仅是一种无意识现象，而是一种知名的神经功能，可以增高从神经增高至脑干文职地带的呼吸困难信号。

这种振荡涉及到了内源性的酚，这种微粒导致自脑干，在减低呼吸困难的过程中扮演着重要角色。研究成果工作人员让大多数人分别顺利完成一个比较简单或者一个较难的记忆性战斗任务，需要他们记住信件的注解段落，同时给大多数人胳膊上施予高热。进行较难战斗任务的大多数人变得心烦意乱时，他们会感到较小的呼吸困难，通过fMRI新科技反映出这些大多数人的神经地带活性变得比较低，fMRI多半是用来测出脑干活性的发生变化。

Sprenger和他的威尔森然后重复了实验，这次他们给予大多数人一种药物-钠洛酮（抗休克的难得药物，可以拦阻吗啡的振荡）或者普通的盐水注入，结果显示，相比只注入普通盐水的大多数人，使用吗啡-HT的大多数人由于视线混杂，引起的呼吸困难加重增高了40%，因此表明内源性的扮演着重要依赖性。

研究成果成果的发掘出探究了无意识过程可以集中地发生变化人们的呼吸困难经历，并且对于临床也有极其重要的意义。研究成果成果回应，我们的研究成果发掘出给呼吸困难疾病外科手术提供了层面行为外科手术的作法。（生物谷：T.Shen解释器）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.